ELAEOCARPUS SERRATUS L. EXHIBITS POTENTIAL ANALGESIC AND ANTIDIARRHEAL ACTIVITIES IN MICE MODEL

Background. Elaeocarpus serratus L. (Family: Elaeocarpaceae) is a tropical fruit tree, traditionally used in the treatments of poisoning, diarrhea, arthritis, and other diseases. Objectives. The current study was performed to conduct analgesic, antidiarrheal, hypoglycemic activity E. mice model using methanolic bark crude extract. Methods. To assess peripheral central analgesic activity, acetic acid-induced writhing tail immersion methods were respectively used. castor-oil mediated antidiarrheal method whereas, tipping technique conducted determine plant Results. In assay, extract significantly inhibits number writing 69.77% (200 mg/kg) 73.26% (400 (p<0.05) which strongly comparable with standard NSAID drug diclofenac sodium 75.58% (p<0.05). Similarly, it shown significant flicking response for 30 minutes, 60 minutes 90 assay. substantially reduced diarrheal feces 64.26% mg/kg, p<0.05) 78.57% also positive control loperamide. not convincing. Conclusions. Our investigation demonstrated activities 400 model.